শনিবার, ৮ জুন, ২০১৩

The Education of a Nurse ? CUNY Newswire ? CUNY

The Education of a Nurse

The nursing program at BMCC is respected across the City for its rigorous standards.

Admittance is contingent on passing the HESI A2 Admission Assessment Exam?a predictor of student success in nursing school?and once enrolled, students must maintain a minimum grade point average in courses including anatomy and physiology. They also complete units on obstetrics, psychiatric nursing and pediatrics.

Justin Vargas is uniquely prepared to meet those challenges.

Before immersing himself in the BMCC nursing program, he took just a few classes and meanwhile, completed the Medical Assistant Specialist (MAS) program in BMCC?s Center for Continuing Education and Workforce Development.

?I would go to continuing ed during the day, nine to five at 25 Broadway, then I?d walk up to the main campus and take the prerequisite courses in the nursing program,? he says.

?In nursing studies there?s a whole language to learn, the medical language. I only had a semester with the medical assisting program, but it put me up there in my nursing classes with people like EMTs who had been working in the medical field for years. I even tutor other students.?

Finding support
Vargas? confidence was kick-started by the support he found in the staff and faculty in BMCC?s continuing education department. ?They care,? he says. ?You can sit for hours after class to go over stuff.?

One person in particular, Wanda Izquierdo-Ortega, Program Manager for Allied Health in adult education, made an impression on him.

?She just told me to do it,? he says. ?She was a coach for me. She sat me down and talked to me with that fiery attitude and gave me the positive reinforcement I needed. It?s not that students aren?t serious, but sometimes we lack confidence.?

As a nursing student, he has completed clinical rotations where he sees first-hand how nursing teams operate in busy urban hospitals.

In one of his clinical rotations, he says, ?The aide had a patient with a catheter. It was full and he kept picking it up above his waist. This was causing infections, but he didn?t know better. Having the MAS certificate gave me the confidence to say to the doctor, ?Hey, he doesn?t know the proper way to carry his catheter bag. He hasn?t been instructed?.?

Honing instincts
Now a full-time nursing student at BMCC, Vargas has completed a psych rotation at Lincoln Hospital in the South Bronx, and completed lab assignments at the New York Simulation Center for Health Sciences (NYSIM), located in Manhattan?s Bellevue Hospital Center.

?The simulators are awesome,? he says of the ?human mannequins? used for training purposes with nursing and medical students from colleges around the City.

?They put you in situations where you can hone your instincts,? he says. ?Here?s an example. We had to respond to a post-partum hemorrhage. You have to feel; you have to palpate the ?patient?. You can hear the respiration, and see the numbers change on the monitors as a nurse enters the data from the patient.?

Role models
Justin Vargas moved to the Bronx with his parents when he was about seven years old. He attended Our Saviour Lutheran High School in the Bronx and after graduating, worked at a Verizon call center.

Next, he worked as an administrative assistant in the Emergency Department at the New York Westchester Square Medical Center in the Bronx?and that piqued his interest in nursing, though his awareness of the field began in childhood.

?My mother?s a nurse, and I saw the way people called her and she gave advice about health issues,? he says. ?She was a hero to me. Then working in a hospital, I saw the level of skills the nurses had. It was awesome. They can take those skills anywhere, any city.?

Another important influence, he says, ?was my best friend?s mother. She?s an alumna of BMCC, and encouraged me to get a certificate, or be a technician of some type in the medical area. She told me, ?Go on the BMCC website, they have everything?.?

Advocating for patients?and other students
?Today, healthcare is moving toward a more holistic approach,? Vargas says.

?Nutrition counseling, for example, is big now. But patient advocacy is my passion. We learn cultural sensitivity in every aspect of our nursing studies, and it helps me, when I do one-to-one now. We sit at arm?s length from a patient and counsel them on how they?re doing.?

Eventually he wants to earn a bachelor?s degree in nursing, specializing in patient advocacy, and his gift for advocacy doesn?t stop with patients.

?Now that I?ve been through it,? he says,? ?I would love to get a peer-to-peer mentoring group from the nursing department to go down to continuing ed and talk to other students like me, about the nursing program at BMCC. It?s the student-to-student support, sometimes, that gets you through.?

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Source: http://www1.cuny.edu/mu/forum/2013/06/07/the-education-of-a-nurse/

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Google says search, ad data predict Box-Office performance

By Lucas Shaw

NEW YORK (TheWrap.com) - Google data about searches for movies, especially trailers, is an increasingly accurate predictor of box-office performance, a new study from the search giant found.

Movie studios and market researchers already turn to Google to examine search trends that could inform their marketing campaigns and box office tracking. Google's new study, titled "Quantifying Movie Magic with Google Search," underscores the utility of that data, and identifies specific areas studios should look at to improve their marketing.

"As moviegoers are increasingly turning to search to learn more about various titles, we have been able to identify general search patterns that give us insight into awareness and intent levels," Google wrote in a blog post Thursday morning.

Google's study found that the amount potential viewers are searching for a trailer in the four weeks before a movie is highly predictive of its opening weekend box office. The study claims that if you look at trailer search volume while considering the time of year and whether the movie is a franchise, you can predict opening weekend box office with 94 percent accuracy.

Moreover, the study found that if a film is searched for at least 250,000 times more than another film in the week before each opens, it will make $4.3 million more that opening weekend.

Should one want to look beyond the opening weekend, the study found a combination of search ad clicks during the week, previous weekend box office, theater count and Rotten Tomatoes score was quite predictive.

Google's emphasis in the study is that moviegoers now look at more information than over, as searches in the movie category increased 56 percent from 2011 to 2012. Moreover, almost half of moviegoers wait to decide what movie to see until the day they see it.

Market research is still adapting to a digital age where some of the best information about consumers is found online rather than outside a movie theater. Though obviously self-interested, Google has provided research arguing its search data is essential to any studio looking to improve its marketing spend.

"By understanding these search patterns, movie marketers are in a better position to align and adjust their strategies to capture the interest of potential moviegoers," the study concludes.

Source: http://news.yahoo.com/google-says-search-ad-data-predict-box-office-005207386.html

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19 Smart Snacks That Burn Fat

Americans love to snack almost as much as we want to lose weight. But according to recent research by the USDA, our snacking habits are adding too many calories and too few nutrients to our diets.

It doesn't have to be this way, says Susan Bowerman, RD, assistant director of the UCLA Center for Human Nutrition. "When done right, [snacking] keeps your energy levels up and gives you more opportunities to get in all your nutritional needs."

Eating snacks with the right ratio of nutrients, with the right calories, will help keep you body energized and help you lose weight. Protein (plus exercise) fuels the growth of lean muscle mass, which boosts metabolic rate and increases calorie burn. Fiber, meanwhile, helps improve digestion and keeps you from binging on fats and sugars.

So while there's no food that will literally "burn fat" while you eat it, smart choices with these ingredients will help your body operate at maximum efficiency. Bowerman suggests snacks under 200 calories, with 10 grams of protein and close to 5 grams of fiber. Here are 20 of our favorite fat-burning snacks.

The Top Fat-Burning Foods

Smart Snacks That Burn Fat

"Almost any fruit is going to make a great snack, but you usually want to pair it with a bit of protein to make it more satisfying," says Bowerman. "Unlike carbohydrates, which get used up relatively quickly, protein will help sustain your energy and hunger levels for a couple of hours."

Our pick for a protein-fruit pairing: one large apple and one cup of skim milk. This duo will give you 10 grams of protein and 5 grams of fiber for just over 200 calories.

The 20 Best Foods for Fiber

Smart Snacks That Burn Fat

Cottage Cheese-Filled Avocado

Here's another fruit and diary combo, this one for when you're craving something rich, creamy, and a bit savory. Remove the pit from one half of an avocado and fill the space with 2 ounces of 1% cottage cheese. For 200 calories, you'll get 9 grams of protein and 7 grams of fiber?and no dirty dishes!

8 Avocado Recipes (Besides Guacamole)

Smart Snacks That Burn Fat

Canned Tuna on Whole-Wheat Crackers

If you don't want to incorporate dairy into every snack, a can of tuna (packaged in water) is another great source of lean protein plus healthy omega-3s. For about 200 calories, you can enjoy 3 ounces of light tuna and 6 whole-wheat crackers?complete with 3 grams of fiber and 20 grams of protein.

Smart Snacks That Burn Fat

Sunflower Lentil Spread With Pita Bread

Lentils are a good source of iron, a metabolism-boosting nutrient that 20% of us don't get enough of. This savory recipe makes four 180-calorie servings, with 10 grams each of protein and fiber.

Try this recipe: Sunflower Lentil Spread

Smart Snacks That Burn Fat

You may not think of shellfish as a grab-and-go snack food, but you can put this tasty treat together in a flash if you keep pre-cooked shrimp on hand. With Greek yogurt and avocado, it's a protein powerhouse with 9 grams per serving (and 4 g fiber), for only 129 calories.

Try this recipe: Shrimp Stack

Smart Snacks That Burn Fat

This recipe, which calls for soy protein powder and low-fat plain yogurt, contains 9 grams of protein; swap in Greek yogurt to add even more. Frozen berries add fiber (4 grams total), and honey provides sweetness. All this for only 139 calories!

Try this recipe: Power Berry Smoothie

Smart Snacks That Burn Fat

Warm Pear With Cinnamon Ricotta

Ricotta cheese is rich in protein, and pears are a good source of fiber. Together with a teaspoon of cinnamon, they make a delicious snack for any time of day. Each serving contains 8 g protein, 5 g fiber, and 170 calories.

Try this recipe: Warm Pear with Cinnamon Ricotta

Smart Snacks That Burn Fat

This recipe is touted as a main course, but it's so light on calories (only 164) that it can stand in as a mid-day snack, as well. It also packs plenty of protein (12 g) thanks to the tofu, as well as 3 grams of fiber.

Try this recipe: Miso-Glazed Tofu

Smart Snacks That Burn Fat

One cup of edamame, or boiled soybeans, contains 17 grams of protein, 8 grams of fiber, and 189 calories. A perfect snack all by itself! Serve hot or cold, season with salt, and enjoy.

Smart Snacks That Burn Fat

Chicken Pita Sandwich (Half)

There's no reason you can't have smaller portions of "real" food as snacks, says Bowerman. "Oftentimes, the healthiest and most balanced snacks are the ones that start as full meals?like a half a sandwich, or a plate of leftovers put together from dinner the night before," she adds.

Whip up this chicken and veggie pita in the morning, and split it in half for two snacks throughout the day. Each half contains 200 calories, 3 grams of fiber, and more than 20 grams of protein.

Try this recipe: Chicken Pita Sandwich

Smart Snacks That Burn Fat

Cauliflower With White Bean Dip

Make a batch of white bean and roasted garlic dip at the beginning of the week to spread on crackers and eat with veggies when hunger strikes. Pair a quarter-cup serving with 2 cups of raw, chopped cauliflower, for example, for a total of 11 grams protein, 8 grams fiber, and 199 calories.

Try this recipe: White Bean and Roasted Garlic Dip

Smart Snacks That Burn Fat

Toast With Walnut and Pear Breakfast Spread

Split this breakfast recipe in half to make a healthy mid-day snack with 200 calories, 11 grams protein, and 3.5 grams fiber. Not only will it help prep your body for fat burn, but it may also boost your energy levels (so you're more likely to get to the gym, perhaps?): Walnuts are rich in serotonin, a hormone that produces feel-good chemicals in the brain.

Try this recipe: Toast with Walnut & Pear Breakfast Spread

Smart Snacks That Burn Fat

Lentil Salad With Tomatoes and Watercress

Salads aren't just for mealtime?when they're about 200 calories, they make a great afternoon snack, as well. This one has 11 grams of protein and 8 grams of fiber, thanks to superfood lentils and plenty of veggies. (The recipe makes six servings, so hold off on adding the vinaigrette if you're not eating the whole thing at once.)

Try this recipe: Lentil Salad with Tomatoes and Watercress

Smart Snacks That Burn Fat

When choosing an energy bar as a snack, the rules are the same: Look for bars with 200 calories or less, 10 grams of protein and close to 5 grams of fiber. The Luna Protein bar certainly comes close (190 calories, 12 g protein, 3 g fiber), and tastes "almost like candy," Health.com testers said.

Smart Snacks That Burn Fat

In the mood for Mexican? You can't go wrong with black beans and veggies: These tostatas cook up quickly and easily for a fast and healthy mini-meal between lunch and dinner. At just over 200 calories, you get 13 grams of protein and 10.5 grams of fiber. Top with tomato salsa for added flavor without fat.

Try this recipe: Veggie Tostadas

Smart Snacks That Burn Fat

Roast Garlic and Edamame Dip

Edamame is a great snack by itself, but it also makes a great ingredient in this creamy dip for raw veggies or whole-wheat pita bread. You can enjoy up to three servings in one snack session, for a total of 162 calories, 9 grams protein and 6 grams fiber.

Try this recipe: Roast Garlic and Edamame Dip

Smart Snacks That Burn Fat

Asparagus and Hard-Boiled Egg

It's no wonder this classic combo goes so well together: Fiber-rich asparagus balances out eggs' natural protein. (Plus, asparagus is known as an aphrodisiac, thanks to its folate and vitamins B6 and E levels. Talk about fun ways to burn fat!)

Pair 15 asparagus spears (cooked or raw) with one hard-boiled egg for a 126-calorie snack, complete with 11 grams of protein and 5 grams of fiber.

Smart Snacks That Burn Fat

A calorie-free beverage doesn't qualify as a real snack, but if you find yourself scouting the kitchen just because you're bored, rather than hungry, this tasty drink may just hit the spot. Plus, green tea has been shown to help dieters lose more weight, according to a study published in the American Journal of Clinical Nutrition, thanks to its metabolism-boosting antioxidant compound called EGCG.

Bowerman says that most research on green tea for weight loss has been inconclusive, but that either way it's a healthy, tasty way to stay hydrated throughout the day. "Drinking water and tea is a good way to keep all of your body's processes, including your metabolism, running smoothly and efficiently," she adds.

Try this recipe: Minty Iced Green Tea

Source: http://abcnews.go.com/Health/Wellness/19-smart-snacks-burn-fat/story?id=19338383

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বৃহস্পতিবার, ২৩ মে, ২০১৩

Cancer Society hits 100 as US cancer rate falls

NEW YORK (AP) ? The American Cancer Society ? one of the nation's best known and influential health advocacy groups ? is 100 years old this week.

Back in 1913 when it was formed, cancer was a lesser threat for most Americans. The biggest killers then were flu, pneumonia, tuberculosis, and stomach bugs. At a time when average life expectancy was 47, few lived long enough to get cancer.

But 15 doctors and businessmen in New York City thought cancer deserved serious attention, so they founded the American Society for the Control of Cancer. The modern name would come 31 years later.

The cancer society's rise coincided with the taming of infectious diseases and lengthening life spans. "Cancer is a disease of aging, so as people live longer there will be more cancer," explained Dr. Michael Kastan, executive director of Duke University's Cancer Institute.

Cancer became the nation's No. 2 killer in 1938, a ranking it has held ever since. It also became perhaps the most feared disease ? the patient's own cells growing out of control, responding only to brutal treatments: surgery, radiation and poisonous chemicals.

The cancer society is credited with being the largest and most visible proponent of research funding, prevention and programs to help house and educate cancer patients.

Last year, the organization had revenues of about $925 million. It employs 6,000 and has 3 million volunteers, calling itself the largest voluntary health organization in the nation.

"The American Cancer Society really is in a league of its own," Kastan said. The rate of new cancer cases has been trending downward ever so slightly.

Some historical highlights:

1913 ? The American Society for the Control of Cancer is founded in New York City.

1944 ? The organization is renamed the American Cancer Society. The change is spurred by Mary Lasker, the wife of advertising mogul Albert Lasker.

1946 ? A research program is launched, built on $1 million raised by Mary Lasker. A year later, Dr. Sidney Farber of Boston announces the first successful chemotherapy treatment.

1948 ? The cancer society pushes the Pap test, which has been credited with driving a 70 percent decline in uterine and cervical cancer.

1964 ? Prodded by the cancer society and other groups, U.S. Surgeon General Luther Terry issues a report irrefutably linking smoking to cancer.

1971 ? The cancer society helps lead passage of the National Cancer Act to ramp up research money. President Nixon declares a national "war on cancer," which becomes an extended effort derided by some as a "medical Vietnam."

1976 ? The cancer society suggests women 40 and older consider a mammogram if their mother or sisters had breast cancer.

1976 ? The cancer society hosts a California event to encourage smokers to quit for the day. A year later, the annual Great American Smokeout is launched nationally.

1988 ? Atlanta becomes headquarters for the society.

1997 ? The cancer society recommends yearly mammograms for women over 40.

2000 ? Dr. Brian Druker of Oregon reports the first success with "targeted" cancer therapy.

2003 ? The cancer society stops recommending monthly breast self-exams. But it continues to urge annual mammograms for most women over 40, even after a government task force says most don't need screening until 50.

2012 ? The cancer society reports the rate of new cancer cases has been inching down by about half a percent each year since 1999.

Source: http://news.yahoo.com/cancer-society-hits-100-us-cancer-rate-falls-063716332.html

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বুধবার, ২২ মে, ২০১৩

Oklahoma lowers tornado death toll amid frantic search

By Carey Gillam and Ian Simpson

MOORE, Oklahoma (Reuters) - Emergency workers pulled more than 100 survivors from the rubble of homes, schools and a hospital in an Oklahoma town hit by a powerful tornado, and officials on Tuesday sharply lowered the number of deaths caused by the storm.

The 2-mile (3-km) wide tornado tore through Moore outside Oklahoma City on Monday afternoon, trapping victims beneath the rubble.

Seven children died at Plaza Towers Elementary School, which took a direct hit, but many more survived unhurt.

"They literally were lifting walls up and kids were coming out," Oklahoma State Police Sergeant Jeremy Lewis said. "They pulled kids out from under cinder blocks without a scratch on them."

The Oklahoma state medical examiner's office said 24 bodies had been recovered from the wreckage, down from the 51 they had reported earlier. The earlier number likely reflected some double-counted deaths, said Amy Elliott, chief administrative officer for the medical examiner.

"There was a lot of chaos," she said.

Thunderstorms and lightning slowed the rescue effort on Tuesday, but 101 people had been pulled from the debris alive, Oklahoma Highway Patrol spokeswoman Betsy Randolph said.

Firefighters from more than a dozen fire departments and rescuers from other states worked all night under bright spotlights trying to find survivors.

President Barack Obama declared a major disaster area in Oklahoma, ordering federal aid to supplement state and local efforts in Moore after the deadliest U.S. tornado since 161 people were killed in Joplin, Missouri, two years ago.

"The people of Moore should know that their country will remain on the ground, there for them, beside them, as long as it takes," Obama said at the White House.

Glenn Lewis, the mayor of Moore, said the whole town looked like a debris field and there was a danger of electrocution and fire from downed power lines and broken natural gas lines.

"It looks like we have lost our hospital. I drove by there a while ago and it's pretty much destroyed," Lewis told NBC.

The National Weather Service assigned the twister a preliminary ranking of EF4 on the Enhanced Fujita Scale, meaning the second most powerful category of tornado with winds up to 200 mph.

The National Weather Service Storm Prediction Center warned the town 16 minutes before the tornado touched down at 3:01 p.m. (2001 GMT), which is more than the average eight to 10 minutes of warning, said Keli Pirtle, a spokeswoman for the center in Norman, Oklahoma.

SCHOOL TRAGEDY

U.S. Representative Tom Cole, who lives in Moore, said the Plaza Towers school was the most secure and structurally strong building in the area.

"And so people did the right thing, but if you're in front of an F4 or an F5 there is no good thing to do if you're above ground. It's just tragic," he said on MSNBC TV.

At least 60 of the 240 people injured were children, hospital officials said.

Witnesses said Monday's tornado appeared more fierce than the giant twister that was among the dozens that tore up the area on May 3, 1999, killing more than 40 people and destroying thousands of homes. That tornado ranked as an EF5 tornado with wind speeds of more than 200 mph.

The 1999 tornado ranks as the third-costliest tornado in U.S. history, having caused more than $1 billion in damage at the time, or more than $1.3 billion in today's dollars. Only the devastating Joplin and Tuscaloosa tornadoes in 2011 were more costly.

Monday's tornado in Moore ranks among the most severe in the United States http://link.reuters.com/gec38t

Jeff Alger, 34, who works in the Kansas oil fields on a fracking crew, said his wife Sophia took their children out of school when she heard a tornado was coming and then fled Moore and watched it flatten the town from a few miles away.

"They didn't even have time to grab their shoes," said Alger, who has five children aged 4 to 11. The storm tore part of the roof off of his home. He was with his wife at Norman Regional Hospital to have glass and other debris removed from his wife's bare feet.

Moore was devastated with debris everywhere, street signs gone, lights out, houses destroyed and vehicles tossed about as if they were toys.

The dangerous storm system threatened several southern Plains states with more twisters.

SAVED BY CELLPHONE

Speaking outside Norman Regional Hospital Ninia Lay, 48, said she huddled in a closet through two storm alerts and the tornado hit on the third.

"I was hiding in the closet and I heard something like a train coming," she said under skies still flashing with lightning. The house was flattened and Lay was buried in the rubble for two hours until her husband Kevin, 50, and rescuers dug her out.

"I thank God for my cell phone, I called me husband for help."

Her 7-year-old daughter Catherine, a first-grader at Plaza Towers Elementary School, took shelter with classmates and teachers in a bathroom when the tornado hit and destroyed the school. She escaped with scrapes and cuts.

Briarwood Elementary School, which also stood in the storm's path, was all but destroyed. On the first floor, sections of walls had been peeled away, giving clear views into the building; while in other areas, cars hurled by the storm winds were lodged in the walls.

At Southmoore High School in Moore, about 15 students were in a field house when the tornado hit. Coaches sent them to an interior locker room and made them put on football helmets, and all survived, the Oklahoman newspaper said.

(Additional reporting by Alice Mannette, Lindsay Morris, Nick Carey, Brendan O'Brien and Greg McCune; Writing by Nick Carey and Jane Sutton; Editing by W Simon and Grant McCool)

Source: http://news.yahoo.com/monster-tornado-devastates-oklahoma-town-least-37-dead-010033332.html

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Team finds mechanism linking key inflammatory marker to cancer

Monday, May 20, 2013

In a new study described in the journal Oncogene, researchers reveal how a key player in cell growth, immunity and the inflammatory response can be transformed into a primary contributor to tumor growth.

Scientists call this Jekyll-and-Hyde molecule NF-kappa B. In healthy cells, it is a powerful "first responder," a vital part of the body's immune and inflammatory responses. It spends most of its life in the cell's cytoplasm, quietly awaiting orders. But when extracellular signals ? of a viral or bacterial invasion, for example ? set off chemical alarms, the cell unchains this warhorse, allowing it to go into the nucleus where it spurs a flurry of defensive activity, including the transcription of genes that trigger inflammation, promote cell proliferation and undermine cell death.

Researchers have known for years that a hyperactive form of NF-kappa B that gets into the nucleus and stays there is associated with various cancers. But they didn't know what was keeping it active in the nucleus.

"Normally in the cell NF-kappa B is in the cytosol, it's not in the nucleus, and it's not activated," said University of Illinois medical biochemistry professor Lin-Feng Chen, who led the new study. "You have to stimulate normal cells to see NF-kappa B in the nucleus. But in cancer cells without any stimulation you can see this nuclear form of NF-kappa B. The cell just won't die because of this. That is why NF-kappa B is so important in cancer."

In the new study, Chen's group found that another molecule known to help regulate gene expression, called BRD4, recognizes a specific amino acid on a subunit of the NF-kappa B protein complex after the amino acid has been marked with a specific tag, called an acetyl group. This "acetylation" allows the BRD4 to bind to NF-kappa B, activating it and preventing its degradation in cancer cells.

Previous studies had shown that BRD4's recognition of the acetylated subunit increased NF-kappa B activation, but this recognition had not been linked to cancer.

BRD4 belongs to a class of molecules that can recognize chemical markers on other proteins and interact with them to spur the marked proteins to perform new tasks. Chemical "readers" such as BRD4 are important players in the field of epigenetics, which focuses on how specific genes are regulated.

"In epigenetics, there are writers, there are readers and there are erasers," Chen said. The writers make modifications to proteins after they are formed, without changing the underlying sequence of the gene that codes for them. These modifications (such as acetylation) signal other molecules (the readers) to engage with the marked proteins in various ways, allowing the proteins to fulfill new roles in the life of the cell. Epigenetic erasers remove the marks when they are no longer of use.

Such protein modifications "have been shown to be critically involved in transcription regulation and cancer development," the researchers report.

To test whether BRD4 was contributing to the sustained presence of NF-kappa B in the nucleus of cancer cells, Chen and his colleagues exposed lung cancer cells in cell culture and in immune-deficient mice to JQ1, a drug that interferes with BRD4 activity. Exposure to JQ1 blocked the interaction of BRD4 and NF-kappa B, blocked the expression of genes regulated by NF-kappa B, reduced proliferation of lung cancer cells and suppressed the ability of lung cancer cells to induce tumors in immune-deficient mice, the researchers found.

The researchers also discovered that depletion of BRD4 or the treatment of cells with JQ1 induced the degradation of the NF-kappa B subunit recognized by BRD4.

Chen said that BRD4 likely prevents other molecules from recognizing the hyperactive NF-kappa B in the nucleus and marking it for degradation.

"This is an example of how epigenetic regulators and NF-kappa B may one day be targeted for the treatment of cancer," he said.

Researchers from Illinois biochemistry professor Satish Nair's laboratory and from the laboratory of James Bradner at the Dana-Farber Cancer Institute contributed to this study.

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University of Illinois at Urbana-Champaign: http://www.uiuc.edu

Thanks to University of Illinois at Urbana-Champaign for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/128313/Team_finds_mechanism_linking_key_inflammatory_marker_to_cancer

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Protesters chant 'IRS has got to go' in Cincinnati

CINCINNATI (AP) ? Chanting "IRS has got to go," tea party activists are rallying in Cincinnati to protest extra IRS scrutiny of their groups.

Waving such signs as "internal revenge service" and some wearing Colonial-era attire, members of tea party groups gathered Tuesday at the city's Fountain Square.

They plan to march to the nearby federal building. That building houses Internal Revenue Service offices that handled group applications for tax-exempt status. IRS officials have acknowledged that some conservative groups received inappropriate attention and questioning.

Tea party protests of the IRS also were planned in other cities across the country.

Some recent IRS retirees in the Cincinnati area say employees there shouldn't be vilified. Former senior manager Bonnie Esrig says the office was a nonpolitical environment, and tax-exempt status workloads had been increasing.

Source: http://news.yahoo.com/protesters-chant-irs-got-cincinnati-162322679.html

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